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We also matched the data using the JCPDS file

In the end, 36 studies made the final cut, but 35 were animal or cell studies, and only one study involved humans

As FDA states in their guidance document on the Q-Submission program, Early interaction with FDA on planned non-clinical and clinical studies and careful consideration of FDAs feedback may improve the quality of subsequent submissions, shorten total review times, and facilitate the development process for new devices. While this is not meant to be a general pre-review of your submission, it is there to help you get answers to questions directly from FDAwhich will contribute to a smooth submission and, hopefully, approval

Current research trends in NOX inhibitors focus on creating compounds that are both highly effective and specific to individual isoforms, as shown in Figure 2 (Dustin et al., 2023)